The case of a 57-year old woman, apparently in good health, in menopause with familial incidence of breast cancer is discussed. The patient came to the Senology Unit for annual control mammography. For diagnostic completion US was performed: it showed the presence of a hypoechoic neoformation highly suggestive of malignancy (class V BI-RADS). Therefore, US-guided needle aspiration biopsy was performed. It confirmed the malignant nature of the neoformation and surgery was planned. At definitive histological examination a small invasive ductal carcinoma, 6 mm in diameter, was diagnosed.