Kadsuphilactones A and B, two new triterpene dilactones from kadsuraphilippinensis

Org Lett. 2005 Jul 21;7(15):3307-10. doi: 10.1021/ol051155k.

Abstract

[structure: see text]. Two novel triterpene dilactones, kadsuphilactones A (1) and B (2), were isolated from the Taiwanese medicinal plant Kadsura philippinensis. The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic methods, including two-dimensional NMR techniques, and confirmed by X-ray crystallographic analysis. Kadsuphilactone B (2) exhibited in vitro anti-HBV activity with IC(50) values of 6 microg/mL by HBsAg enzyme immunoassay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology
  • Crystallography, X-Ray
  • Hepatitis B virus / drug effects*
  • Inhibitory Concentration 50
  • Kadsura / chemistry*
  • Lactones / chemistry
  • Lactones / isolation & purification*
  • Lactones / pharmacology
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology

Substances

  • Antiviral Agents
  • Lactones
  • Triterpenes
  • kadsuphilactone A
  • kadsuphilactone B