Anaesthesia induced neuroprotection

Robert D Sanders; Daqing Ma; Mervyn Maze

doi:10.1016/j.bpa.2005.01.005

Anaesthesia induced neuroprotection

Best Pract Res Clin Anaesthesiol. 2005 Sep;19(3):461-74. doi: 10.1016/j.bpa.2005.01.005.

Authors

Robert D Sanders¹, Daqing Ma, Mervyn Maze

Affiliation

¹ Department of Anaesthetics and Intensive Care Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Rd, London SW10 9NH, UK. robert.sanders@ic.ac.uk

PMID: 16013694
DOI: 10.1016/j.bpa.2005.01.005

Abstract

Anaesthetic agents display remarkable neuroprotective potential; here, we describe the evidence supporting its use and highlight areas for future development of the field. In particular the application of isoflurane and/or xenon as inhalational neuroprotectants is advocated and evidence for the neuroprotection provided by barbiturates and suppression of cerebral metabolic rate is discussed.

Publication types

Review

MeSH terms

Anesthesia*
Anesthetics, Inhalation / pharmacology
Animals
Humans
Isoflurane / pharmacology
Nervous System Diseases / chemically induced
Nervous System Diseases / prevention & control*
Neurodegenerative Diseases / chemically induced
Neurodegenerative Diseases / prevention & control
Neuroprotective Agents*

Substances

Anesthetics, Inhalation
Neuroprotective Agents
Isoflurane