Abstract
Serum samples obtained from 289 first-time and 114 repeat donors at the Blood Center of Mongolia (MBC) were tested for serological and molecular markers of hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis delta virus (HDV) infections. Among the 403 blood donors, 33 (8.2%), 21 (5.2%), and 27 (6.7%) tested positive for hepatitis B surface antigen (HBsAg) and/or HBV DNA, HCV RNA, and HDV RNA, respectively. Collectively, 55 donors were viremic for one or more of these viruses, and included 54 first-time donors (18.7%) and 1 repeat donor (0.9%) (P < 0.0001). One discrepant case with HBsAg detectable only at MBC was negative for HBsAg, HBV DNA and anti-HBc in this study. Four donors who were HCV-viremic in this study were negative for anti-HCV by the MBC method. Further efforts to increase the sensitivity and specificity of the currently-used tests are urgently required in Mongolia. Three donors who were positive for anti-HBc and anti-HDV but negative for HBsAg, had both HBV DNA and HDV RNA. This suggests that introduction of a new anti-HDV serological test is useful for not only HDV screening but also HBV screening of anti-HBc-positive, HBsAg negative donors, considering a possibility of viral interference by coexisting HDV.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Blood Donors*
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DNA, Viral / blood
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Female
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Hepatitis Antibodies / blood
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Hepatitis B / epidemiology*
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Hepatitis B Antibodies / blood
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Hepatitis B Surface Antigens / blood
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Hepatitis C / epidemiology*
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Hepatitis C Antibodies / blood
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Hepatitis D / epidemiology*
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Hepatitis Delta Virus / immunology
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Humans
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Male
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Middle Aged
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Molecular Sequence Data
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Mongolia / epidemiology
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Phylogeny
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Prevalence
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RNA, Viral / blood
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Sequence Analysis, DNA
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Sequence Homology
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Viremia
Substances
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DNA, Viral
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Hepatitis Antibodies
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Hepatitis B Antibodies
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Hepatitis B Surface Antigens
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Hepatitis C Antibodies
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RNA, Viral
Associated data
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GENBANK/AB206482
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GENBANK/AB206483
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GENBANK/AB206484
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GENBANK/AB206485
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GENBANK/AB206486
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GENBANK/AB206487
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GENBANK/AB206488
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GENBANK/AB206489
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GENBANK/AB206490
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GENBANK/AB206491
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GENBANK/AB206492
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GENBANK/AB206493
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GENBANK/AB206494
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GENBANK/AB206495
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GENBANK/AB206496
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GENBANK/AB206497
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GENBANK/AB206498
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GENBANK/AB206499
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GENBANK/AB206500
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GENBANK/AB206501
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GENBANK/AB206502
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GENBANK/AB206503
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GENBANK/AB206504
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GENBANK/AB206505
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GENBANK/AB206506
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GENBANK/AB206507
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GENBANK/AB206508
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GENBANK/AB206509
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GENBANK/AB206510
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GENBANK/AB206511
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GENBANK/AB206513
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GENBANK/AB206514
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GENBANK/AB206523
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GENBANK/AB206527
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GENBANK/AB206529
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GENBANK/AB206532
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GENBANK/AB206533
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GENBANK/AB206534