2-Pyrone natural products and mimetics: isolation, characterisation and biological activity

Gerard P McGlacken; Ian J S Fairlamb

doi:10.1039/b416651p

2-Pyrone natural products and mimetics: isolation, characterisation and biological activity

Nat Prod Rep. 2005 Jun;22(3):369-85. doi: 10.1039/b416651p. Epub 2005 May 5.

Authors

Gerard P McGlacken¹, Ian J S Fairlamb

Affiliation

¹ Department of Chemistry, University of York, Heslington, York, UK YO10 5DD.

PMID: 16010346
DOI: 10.1039/b416651p

Abstract

The review summarises natural products containing the 2-pyrone moiety. An emphasis has been placed upon the biological activity associated with 2-pyrones, particularly with respect to potential therapeutic or anti-microbial agents. Where appropriate, non-natural 2-pyrone analogues are discussed, particularly those derived from natural product lead compounds.

Publication types

Review

MeSH terms

Alzheimer Disease / drug therapy
Anti-HIV Agents / chemistry
Anti-HIV Agents / isolation & purification
Anti-HIV Agents / pharmacology
Anticholesteremic Agents / chemistry
Anticholesteremic Agents / isolation & purification
Anticholesteremic Agents / pharmacology
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology
Biological Products* / chemistry
Biological Products* / isolation & purification
Biological Products* / pharmacology
Molecular Mimicry
Molecular Structure
Pyrones* / chemistry
Pyrones* / isolation & purification
Pyrones* / pharmacology

Substances

Anti-HIV Agents
Anticholesteremic Agents
Antineoplastic Agents
Biological Products
Pyrones