Distinguishing acute-onset CIDP from Guillain-Barré syndrome with treatment related fluctuations

Neurology. 2005 Jul 12;65(1):138-40. doi: 10.1212/01.wnl.0000167549.09664.b8.

Abstract

Guillain-Barré syndrome (GBS) patients may worsen after initial treatment (treatment-related fluctuation [TRF]). It is difficult to distinguish GBS-TRF from chronic inflammatory demyelinating polyneuropathy with acute onset (A-CIDP). The authors compared 13 patients with A-CIDP with 11 patients with GBS-TRF and concluded that A-CIDP should be suspected when a patient with GBS deteriorates after 9 weeks from onset or when deterioration occurs three times or more. Maintenance treatment should then be considered.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Chronic Disease
  • Cranial Nerve Diseases / diagnosis
  • Cranial Nerve Diseases / etiology
  • Cranial Nerve Diseases / physiopathology
  • Diagnosis, Differential
  • Diagnostic Errors / prevention & control*
  • Disability Evaluation
  • Disease Progression
  • Female
  • Guillain-Barre Syndrome / diagnosis*
  • Guillain-Barre Syndrome / physiopathology
  • Guillain-Barre Syndrome / therapy
  • Humans
  • Infant, Newborn
  • Male
  • Middle Aged
  • Muscle Weakness / diagnosis
  • Muscle Weakness / etiology
  • Muscle Weakness / physiopathology
  • Neurologic Examination
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / diagnosis*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / physiopathology
  • Predictive Value of Tests
  • Prognosis
  • Recurrence
  • Time Factors