This paper reports upon two case studies addressing the short-term effects of Qi therapy on symptoms of cancer in two terminally ill oncology patients. Changes in anxiety state, pain, discomfort, depression, mood, alertness, and fatigue in two cancer patients were assessed. Treatment involved four therapy sessions on alternate days over a 7-day period. After 20 min of Qi therapy, both patients experienced improvements in mood and alertness, and a reduction in pain, anxiety, depression, discomfort, and fatigue, on both the first and last days of the interventions. Furthermore, the scores recorded on the last day for most symptoms were improved than those recorded on the first day. Although the results of these two case studies do not constitute conclusive evidence, the data suggest that Qi therapy may have some beneficial effects on some symptoms of cancer.