Fatal reactivation of postnatal cytomegalovirus infection with rapid emergence of ganciclovir resistance in an infant after allogeneic stem cell transplantation

J Clin Microbiol. 2005 Jul;43(7):3551-4. doi: 10.1128/JCM.43.7.3551-3554.2005.

Abstract

Human cytomegalovirus (HCMV) can cause serious problems after hematopoietic stem cell transplantation. The death of a pediatric transplant recipient after reactivation of a postnatal HCMV infection with bilateral retinitis and pneumonitis is described. Sequencing of the HCMV UL97 region revealed a compartment-specific mutation (H520Q) in urine conferring ganciclovir resistance.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / pharmacology
  • Cytomegalovirus / drug effects*
  • Cytomegalovirus / genetics
  • Cytomegalovirus / physiology
  • Cytomegalovirus Retinitis / virology
  • Fatal Outcome
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Infant
  • Phosphotransferases (Alcohol Group Acceptor) / genetics
  • Pneumonia / virology
  • Transplantation, Homologous / adverse effects*
  • Virus Activation*

Substances

  • Antiviral Agents
  • Phosphotransferases (Alcohol Group Acceptor)
  • ganciclovir kinase