The plant lignans matairesinol and secoisolariciresinol administered to Min mice do not protect against intestinal tumor formation

Cancer Lett. 2006 Feb 28;233(2):309-14. doi: 10.1016/j.canlet.2005.03.061. Epub 2005 Jul 5.

Abstract

The lignans matairesinol (MAT) and secoisolariciresinol (SECO) were fed to Min mice at 0.02% (w/w) in diet to study their effects on intestinal tumor development. The mean number (67 vs. 51, P=0.052) and size (1.4 vs. 1.2 mm, P=0.011) of tumors in the MAT group was elevated when compared with the control group. Tumor formation of the SECO group did not differ from the control group. Intake of MAT increased the level of both MAT and enterolactone in the plasma while SECO feeding increased SECO, enterodiol, and enterolactone (P=0.001). These results showed that MAT or SECO do not prevent intestinal carcinogenesis in Min mice and that MAT may have adverse effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Butyrolactone / analogs & derivatives
  • 4-Butyrolactone / blood
  • Adenomatous Polyposis Coli Protein / genetics
  • Adenomatous Polyposis Coli Protein / physiology*
  • Animals
  • Butylene Glycols / administration & dosage*
  • Diet
  • Disease Models, Animal
  • Female
  • Furans / administration & dosage*
  • Intestinal Neoplasms / prevention & control*
  • Lignans / administration & dosage*
  • Lignans / blood
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Plants / chemistry*

Substances

  • Adenomatous Polyposis Coli Protein
  • Butylene Glycols
  • Furans
  • Lignans
  • matairesinol
  • secoisolariciresinol
  • 4-Butyrolactone
  • 2,3-bis(3'-hydroxybenzyl)butyrolactone