In situ-gelling, erodible N-isopropylacrylamide copolymers

Macromol Biosci. 2005 Jul 14;5(7):629-35. doi: 10.1002/mabi.200500029.

Abstract

Copolymers of N-isopropylacrylamide, 2-hydroxyethyl methacryl lactate [(HEMA)-lactate] and acrylic acid (AAc) were prepared with varying mole ratios of monomers to develop copolymers with gelation properties above a certain concentration for a bioerodible, in-situ gelling material. The copolymers formed gels in situ under physiological condition. The gelation temperature of the copolymers decreased as the HEMA-lactate content of the copolymers increased due to the hydrophobicity of HEMA-lactate, and increased as the AAc content increased due to the hydrophilicity of AAc. The gels redissolve at 37 degrees C as their LCSTs increase above 37 degrees C due to the hydrolysis of the HEMA-lactate pendant groups.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acrylamides / chemistry*
  • Acrylates / chemistry
  • Biocompatible Materials / chemical synthesis
  • Biocompatible Materials / chemistry*
  • Gels / chemical synthesis
  • Gels / chemistry*
  • Hydrolysis
  • Lactates / chemistry
  • Methacrylates / chemistry
  • Polymers / chemical synthesis
  • Polymers / chemistry*
  • Temperature

Substances

  • Acrylamides
  • Acrylates
  • Biocompatible Materials
  • Gels
  • Lactates
  • Methacrylates
  • Polymers
  • hydroxyethyl methacrylate
  • N-isopropylacrylamide
  • acrylic acid