New bicyclic taxane diterpenoids from Taxus sumatrana

Chem Pharm Bull (Tokyo). 2005 Jul;53(7):808-10. doi: 10.1248/cpb.53.808.

Abstract

Investigation of an acetone extract of the leaves and twigs of Taxus sumatrana has resulted in the isolation of two new bicyclic taxoids, tasumatrols M (1), and N (2) and a new baccatin III derivative, tasumatrol O (3) together with the previous known 7-deacetylcanadensene (4) and 2alpha,7beta,13alpha-triacetoxy-5alpha,9alpha-dihydroxy-2(3-->20) abeotaxa-4(20),11-dien-10-one. The structures of these taxanes were established on the basis of spectroscopic analyses, especially 1- and 2D NMR, and chemical derivatization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bridged Bicyclo Compounds / chemistry
  • Bridged Bicyclo Compounds / isolation & purification*
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Taxoids / chemistry
  • Taxoids / isolation & purification*
  • Taxus / chemistry*

Substances

  • Bridged Bicyclo Compounds
  • Diterpenes
  • Taxoids