The CYP1A1*2a allele is an independent prognostic factor for acute myeloid leukemia

Haematologica. 2005 Jul;90(7):982-4.

Abstract

Polymorphisms in carcinogen- and drug-metabolizing enzymes may increase the risk of acute myeloid leukemia (AML) and may influence prognosis. We report that the polymorphic variant of the cytochrome P450 CYP1A1*2A, present in 11.3% of patients, is an independent unfavorable prognostic factor for failure-free and overall survival in patients with AML.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Alleles*
  • Cytochrome P-450 CYP1A1 / genetics*
  • Cytogenetics
  • Disease-Free Survival
  • Genetic Predisposition to Disease*
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / mortality
  • Polymorphism, Genetic
  • Prognosis
  • Remission Induction
  • Risk
  • Treatment Outcome

Substances

  • Cytochrome P-450 CYP1A1