Prospective trial of electroanatomically guided, irrigated catheter ablation of atrial tachycardia in patients with congenital heart disease

Heart Rhythm. 2005 Jul;2(7):700-5. doi: 10.1016/j.hrthm.2005.03.017.

Abstract

Background: Ablation success rates reported for atrial tachycardia (AT) patients with congenital heart disease (CHD) is lower than the rates reported for other varieties of supraventricular tachycardia. Retrospective studies suggest these rates might be increased by the use of irrigated radiofrequency (RF) ablation.

Objectives: The purpose of this study was to determine whether irrigated RF ablation increases ablation success rates in patients with CHD and AT.

Methods: Patients were studied in a prospective, randomized, nonblinded manner. The operator was limited to use of randomized therapy (standard or irrigated ablation) for the first 6 minutes of RF application to each targeted arrhythmia. Lesion characteristics were recorded, and acute ablation success was ascertained. Structured clinical follow-up was performed over a 6-month period.

Results: Forty-seven ATs were targeted in 26 patients; 72% of these ATs were ablated. Within the 6-minute randomization period, no difference in success rates of standard and irrigated catheters was noted. However, crossover from standard to irrigated ablation more likely was successful than vice versa (irrigated: 8 successes/8 attempts vs standard: 1 success/4 attempts, P = .018), and overall success was greater using irrigated catheters (66% vs 33%, P = .019). Mean delivered power was slightly higher in irrigated lesions (32.5 W vs 30.2 W, P = .025), and mean temperature was much lower (33.5 degrees C vs 59.3 degrees C, P < .001). A composite AT intensity score was significantly reduced compared with preablation values at 6-month follow-up of all patients.

Conclusions: Ablation of ATs in patients with CHD results in symptomatic improvement over short-term follow-up. Irrigated ablation may result in higher acute success rates in these patients.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Catheter Ablation / methods*
  • Cold Temperature
  • Cross-Over Studies
  • Female
  • Follow-Up Studies
  • Heart Defects, Congenital / complications*
  • Heart Defects, Congenital / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Tachycardia, Ectopic Atrial / etiology*
  • Tachycardia, Ectopic Atrial / physiopathology
  • Tachycardia, Ectopic Atrial / surgery*
  • Therapeutic Irrigation
  • Treatment Outcome