Abstract
A new study of dominant negative functions in cells infected by a positive-strand RNA virus detects an array of locus- and allele-specific effects. Exploiting subunit defects in multi-component complex assemblies provides a new approach to identifying targets for antiviral therapies that may inhibit the emergence of drug-resistant RNA virus populations.
MeSH terms
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Alleles
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Antiviral Agents / pharmacology
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Cysteine Endopeptidases / genetics
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Drug Resistance, Viral*
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Genome, Viral*
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Mutation
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Poliovirus / genetics*
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Poliovirus / physiology
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Viral Proteins / genetics*
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Virus Replication / drug effects
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Virus Replication / genetics*
Substances
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Antiviral Agents
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Viral Proteins
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Cysteine Endopeptidases
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picornain 2A, Picornavirus