Abstract
The present study investigated the vasorelaxant action of the aqueous leaves extract of Persea americana on isolated rat aorta. The results showed that the extract produced significant vasorelaxation and that the effect is dependent on the synthesis or release of endothelium-derived relaxing factors (EDRFs) as well as the release of prostanoid. The extract also reduced vasoconstriction probably by inhibiting Ca2+ influx through calcium channels.
MeSH terms
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Animals
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Aorta, Thoracic / drug effects*
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Dose-Response Relationship, Drug
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Female
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Male
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Muscle, Smooth, Vascular / drug effects
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Norepinephrine
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Persea*
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Leaves
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Potassium Chloride
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Rats
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Rats, Sprague-Dawley
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Vasoconstriction / drug effects
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Vasodilator Agents / administration & dosage
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Vasodilator Agents / pharmacology*
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Vasodilator Agents / therapeutic use
Substances
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Plant Extracts
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Vasodilator Agents
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Potassium Chloride
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Norepinephrine