Life, death, and ubiquitin: taming the mule

Cell. 2005 Jul 1;121(7):963-5. doi: 10.1016/j.cell.2005.06.018.

Abstract

Ubiquitin-mediated protein degradation is an efficient way for the cell to get rid of unwanted proteins. A key player in this process is the E3 ubiquitin ligase. In this issue of Cell, and describe a new E3 ligase, ARF-BP1/Mule, which targets two very different substrates, p53 and Mcl-1, with completely different cellular outcomes.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Cell Survival / physiology
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / metabolism
  • Humans
  • Myeloid Cell Leukemia Sequence 1 Protein
  • Neoplasm Proteins / metabolism*
  • Protein Binding / physiology
  • Proto-Oncogene Proteins c-bcl-2 / metabolism*
  • Signal Transduction / physiology
  • Tumor Suppressor Protein p53 / metabolism*
  • Ubiquitin / metabolism*
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / metabolism*

Substances

  • Myeloid Cell Leukemia Sequence 1 Protein
  • Neoplasm Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Tumor Suppressor Protein p53
  • Ubiquitin
  • Ubiquitin-Protein Ligases