Abstract
Activity-dependent long-term potentiation (LTP) in the CNS is thought to be important in learning, memory, development, and persistent pain. Here, we report that NMDA receptor-dependent LTP is the major form of long-term plasticity in the anterior cingulate cortex (ACC). In addition to N-methyl-D-aspartate (NMDA) receptors, L-type voltage-gated calcium channels are also required for inducing LTP. Activation of calcium-stimulated adenylyl cyclase subtype 1 (AC1) is essential for the induction of LTP in ACC neurons, while AC8 subunit partially contributes to forskolin-induced potentiation. Our results suggest that calcium-stimulated cAMP-dependent signaling pathways play a critical role in cingulate LTP.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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6-Cyano-7-nitroquinoxaline-2,3-dione / pharmacology
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Adenine / analogs & derivatives*
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Adenine / pharmacology
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Adenylyl Cyclases / classification
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Adenylyl Cyclases / deficiency
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Adenylyl Cyclases / physiology*
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Animals
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Calcium / metabolism*
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Calcium Channel Blockers / pharmacology
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Colforsin / pharmacology
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Dose-Response Relationship, Drug
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Drug Interactions
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Electric Stimulation / methods
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Enzyme Inhibitors / pharmacology
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Excitatory Amino Acid Agonists / pharmacology
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Excitatory Amino Acid Antagonists / pharmacology
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GABA Antagonists / pharmacology
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Gyrus Cinguli / drug effects
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Gyrus Cinguli / physiology*
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In Vitro Techniques
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Long-Term Potentiation / drug effects
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Long-Term Potentiation / physiology*
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Long-Term Potentiation / radiation effects
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Nifedipine / pharmacology
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Patch-Clamp Techniques / methods
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Picrotoxin / pharmacology
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology
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Synaptic Transmission / radiation effects
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Time Factors
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Valine / analogs & derivatives*
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Valine / pharmacology
Substances
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Calcium Channel Blockers
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Enzyme Inhibitors
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Excitatory Amino Acid Agonists
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Excitatory Amino Acid Antagonists
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GABA Antagonists
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Picrotoxin
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9-(tetrahydro-2-furyl)-adenine
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Colforsin
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6-Cyano-7-nitroquinoxaline-2,3-dione
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2-amino-5-phosphopentanoic acid
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Adenylyl Cyclases
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Valine
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Nifedipine
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Adenine
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Calcium