Calcium-stimulated adenylyl cyclases required for long-term potentiation in the anterior cingulate cortex

J Neurophysiol. 2005 Jul;94(1):878-82. doi: 10.1152/jn.01205.2004.

Abstract

Activity-dependent long-term potentiation (LTP) in the CNS is thought to be important in learning, memory, development, and persistent pain. Here, we report that NMDA receptor-dependent LTP is the major form of long-term plasticity in the anterior cingulate cortex (ACC). In addition to N-methyl-D-aspartate (NMDA) receptors, L-type voltage-gated calcium channels are also required for inducing LTP. Activation of calcium-stimulated adenylyl cyclase subtype 1 (AC1) is essential for the induction of LTP in ACC neurons, while AC8 subunit partially contributes to forskolin-induced potentiation. Our results suggest that calcium-stimulated cAMP-dependent signaling pathways play a critical role in cingulate LTP.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 6-Cyano-7-nitroquinoxaline-2,3-dione / pharmacology
  • Adenine / analogs & derivatives*
  • Adenine / pharmacology
  • Adenylyl Cyclases / classification
  • Adenylyl Cyclases / deficiency
  • Adenylyl Cyclases / physiology*
  • Animals
  • Calcium / metabolism*
  • Calcium Channel Blockers / pharmacology
  • Colforsin / pharmacology
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Electric Stimulation / methods
  • Enzyme Inhibitors / pharmacology
  • Excitatory Amino Acid Agonists / pharmacology
  • Excitatory Amino Acid Antagonists / pharmacology
  • GABA Antagonists / pharmacology
  • Gyrus Cinguli / drug effects
  • Gyrus Cinguli / physiology*
  • In Vitro Techniques
  • Long-Term Potentiation / drug effects
  • Long-Term Potentiation / physiology*
  • Long-Term Potentiation / radiation effects
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Nifedipine / pharmacology
  • Patch-Clamp Techniques / methods
  • Picrotoxin / pharmacology
  • Synaptic Transmission / drug effects
  • Synaptic Transmission / physiology
  • Synaptic Transmission / radiation effects
  • Time Factors
  • Valine / analogs & derivatives*
  • Valine / pharmacology

Substances

  • Calcium Channel Blockers
  • Enzyme Inhibitors
  • Excitatory Amino Acid Agonists
  • Excitatory Amino Acid Antagonists
  • GABA Antagonists
  • Picrotoxin
  • 9-(tetrahydro-2-furyl)-adenine
  • Colforsin
  • 6-Cyano-7-nitroquinoxaline-2,3-dione
  • 2-amino-5-phosphopentanoic acid
  • Adenylyl Cyclases
  • Valine
  • Nifedipine
  • Adenine
  • Calcium