Sublethal concentrations of ciprofloxacin induce bacteriocin synthesis in Escherichia coli

Borut Jerman; Matej Butala; Darja Zgur-Bertok

doi:10.1128/AAC.49.7.3087-3090.2005

Sublethal concentrations of ciprofloxacin induce bacteriocin synthesis in Escherichia coli

Antimicrob Agents Chemother. 2005 Jul;49(7):3087-90. doi: 10.1128/AAC.49.7.3087-3090.2005.

Authors

Borut Jerman¹, Matej Butala, Darja Zgur-Bertok

Affiliation

¹ Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, Ljubljana, Slovenia.

Abstract

Antibiotics that interfere with DNA replication, as well as cell wall synthesis, induce the SOS response. In this report, we show that ciprofloxacin induces synthesis of colicins, narrow-spectrum antibiotics frequently produced by Escherichia coli strains, in an SOS-dependent manner.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Ciprofloxacin / pharmacology*
Colicins / biosynthesis*
Escherichia coli / drug effects*
Escherichia coli / genetics
Escherichia coli / metabolism
Escherichia coli Proteins / genetics
Escherichia coli Proteins / metabolism*
Gene Expression Regulation, Bacterial*
SOS Response, Genetics

Substances

Anti-Bacterial Agents
Colicins
Escherichia coli Proteins
Ciprofloxacin