Idiopathic hypereosinophilic syndrome: a case evolving in B-lymphoblastic lymphoma

Maria Cristina Rapanotti; Roberta Caruso; Sergio Bernardini; Valentina Coletti; Francesco Lo-Coco; Giulio De Rossi

doi:10.1016/j.leukres.2005.01.010

Idiopathic hypereosinophilic syndrome: a case evolving in B-lymphoblastic lymphoma

Leuk Res. 2005 Aug;29(8):975-9. doi: 10.1016/j.leukres.2005.01.010. Epub 2005 Mar 2.

Authors

Maria Cristina Rapanotti¹, Roberta Caruso, Sergio Bernardini, Valentina Coletti, Francesco Lo-Coco, Giulio De Rossi

Affiliation

¹ Dipartimento di Medicina Interna, Facoltà di Medicina e Chirurgia, University Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.

PMID: 15978951
DOI: 10.1016/j.leukres.2005.01.010

Abstract

Idiopathic hypereosinophilic syndrome (HES) is a rare disease characterized by tissue involvement and organ dysfunction due to abnormal eosinophil proliferation. Evolution of HES into myeloid or T-cell malignancies has been frequently reported. Here, we describe a case of HES that preceded the occurrence of a high-grade B-lymphoblastic lymphoma in which clonal evolution has been demonstrated at the molecular level.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Hypereosinophilic Syndrome / complications*
Hypereosinophilic Syndrome / diagnosis
Infant
Lymphoma, B-Cell / complications*
Lymphoma, B-Cell / diagnosis
Lymphoma, B-Cell / genetics
Oncogene Proteins, Fusion / genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
Remission Induction
Reverse Transcriptase Polymerase Chain Reaction
Transcription, Genetic

Substances

Oncogene Proteins, Fusion