Design in silico, synthesis and binding evaluation of a carbohydrate-based scaffold for structurally novel inhibitors of matrix metalloproteinases

Chembiochem. 2005 Aug;6(8):1345-9. doi: 10.1002/cbic.200400456.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding, Competitive
  • Computer Simulation
  • Crystallography, X-Ray
  • Drug Design
  • Glycopeptides / chemical synthesis*
  • Glycopeptides / chemistry
  • Glycopeptides / pharmacology
  • Ligands
  • Matrix Metalloproteinase 12
  • Matrix Metalloproteinase Inhibitors*
  • Matrix Metalloproteinases / chemistry*
  • Metalloendopeptidases / antagonists & inhibitors*
  • Metalloendopeptidases / chemistry*
  • Models, Molecular
  • Molecular Structure
  • Protein Structure, Tertiary
  • Structure-Activity Relationship

Substances

  • Glycopeptides
  • Ligands
  • Matrix Metalloproteinase Inhibitors
  • Matrix Metalloproteinases
  • Metalloendopeptidases
  • Matrix Metalloproteinase 12