This paper overviews the problem of the clinical basis, diagnosis and available therapy modalities for lymphoedema. Regarding diagnostics, the measurement of circumference, volume and thickness of the limb are presented, as well as diagnostic imaging modalities. These include direct and indirect lymphography, MRI, CT, ultrasound imaging and lymphoscintigraphy, which is currently considered the leading technique in primary diagnosis of lymphoedema and its follow-up. This paper discusses the treatment of lymphoedema and the role of lymphoscintigraphy in the follow-up of patents with lymphoedema.