Cytotoxic constituents of the fruit body of Daedalea dickisii

J Nat Prod. 2005 Jun;68(6):911-4. doi: 10.1021/np058024c.

Abstract

Three new lanostane triterpenoids (1, 7, 8) and five new lanostane triterpene glucosides (2-6) have been isolated from the fruit bodies of Daedalea dickinsii. Their structures were established primarily by NMR experiments, and their biological activity against HL-60 and HCT-15 cell lines was investigated. Compounds 3-6 induced internucleosomal DNA fragmentation characteristic of apoptotic cell death in the HL-60 cell line.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • DNA Fragmentation
  • Drug Screening Assays, Antitumor
  • Fruiting Bodies, Fungal / chemistry
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Glucosides / pharmacology
  • HL-60 Cells
  • Humans
  • Japan
  • Lanosterol / analogs & derivatives*
  • Lanosterol / chemistry
  • Lanosterol / isolation & purification*
  • Lanosterol / pharmacology
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Polyporaceae / chemistry*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Glucosides
  • Triterpenes
  • Lanosterol