Abstract
Three new lanostane triterpenoids (1, 7, 8) and five new lanostane triterpene glucosides (2-6) have been isolated from the fruit bodies of Daedalea dickinsii. Their structures were established primarily by NMR experiments, and their biological activity against HL-60 and HCT-15 cell lines was investigated. Compounds 3-6 induced internucleosomal DNA fragmentation characteristic of apoptotic cell death in the HL-60 cell line.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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DNA Fragmentation
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Drug Screening Assays, Antitumor
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Fruiting Bodies, Fungal / chemistry
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology
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HL-60 Cells
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Humans
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Japan
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Lanosterol / analogs & derivatives*
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Lanosterol / chemistry
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Lanosterol / isolation & purification*
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Lanosterol / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Polyporaceae / chemistry*
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Glucosides
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Triterpenes
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Lanosterol