Superantigens

Curr Opin Immunol. 1992 Feb;4(1):74-8. doi: 10.1016/0952-7915(92)90129-3.

Abstract

Over the past three years superantigens have come to the forefront of immunological research. Studies in a number of laboratories have indicated that superantigens play a central role in shaping the T-cell repertoire in the development of tolerance, autoimmunity and immunodeficiency. This is in addition to their classic role in the pathogenesis of a number of infectious diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens / immunology*
  • Antigens, Bacterial / immunology
  • Antigens, Viral / immunology
  • Autoantigens / immunology
  • Autoimmune Diseases / immunology
  • Binding Sites
  • Histocompatibility Antigens Class II / immunology
  • Humans
  • Lymphocyte Activation
  • Mice
  • Receptors, Antigen, T-Cell / immunology
  • Retroviridae / immunology
  • Signal Transduction
  • T-Lymphocyte Subsets / immunology*

Substances

  • Antigens
  • Antigens, Bacterial
  • Antigens, Viral
  • Autoantigens
  • Histocompatibility Antigens Class II
  • Receptors, Antigen, T-Cell