Abstract
Emergence of the newly identified 16S rRNA methylases RmtA, RmtB, and ArmA in pathogenic gram-negative bacilli has been a growing concern. ArmA, which had been identified exclusively in Europe, was also found in several gram-negative pathogenic bacilli isolated in Japan, suggesting global dissemination of hazardous multiple aminoglycoside resistance genes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aminoglycosides / pharmacology*
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Dibekacin / analogs & derivatives*
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Dibekacin / pharmacology
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Drug Resistance, Multiple, Bacterial / genetics*
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Genes, Bacterial
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Global Health*
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Gram-Negative Bacteria / drug effects
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Gram-Negative Bacteria / enzymology
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Gram-Negative Bacteria / genetics
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Gram-Negative Bacterial Infections / epidemiology
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Gram-Negative Bacterial Infections / microbiology
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Gram-Negative Bacterial Infections / transmission*
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Humans
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Methyltransferases / genetics*
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Methyltransferases / metabolism
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Microbial Sensitivity Tests
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RNA, Ribosomal, 16S / genetics
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RNA, Ribosomal, 16S / metabolism
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Bacterial Proteins
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RNA, Ribosomal, 16S
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Dibekacin
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Methyltransferases
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rRNA (adenosine-O-2'-)methyltransferase
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arbekacin