Study of electrochemical oxidation and determination of albendazole using a glassy carbon-rotating disk electrode

Farmaco. 2005 Aug;60(8):671-4. doi: 10.1016/j.farmac.2005.05.004.

Abstract

In this work, electrochemical oxidation of albendazole (ABZ) was carried out using a glassy carbon-rotating disk electrode. Development of electroanalytical methodology for ABZ quantification in pharmaceutical formulations was also proposed by using linear sweep voltammetric technique. Electrochemical oxidation is observed for ABZ at E(1/2)=0.99 V vs. Ag/AgCl(sat), when an anodic wave is observed. Kinetic parameters obtained for ABZ oxidation exhibited a standard heterogeneous rate constant for the electrodic process equal to (1.51+/-0.07) x 10(-5) cm s(-1), with a alphan(a) value equal to 0.76. Limiting current dependence against ABZ concentration exhibited linearity on 5.0 x 10(-5) to 1.0 x 10(-2) mol l(-1) range, being obtained a detection limit of 2.4 x 10(-5) mol l(-1). Proposed methodology was applied to ABZ quantification in pharmaceutical formulations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Albendazole / chemistry*
  • Carbon / chemistry*
  • Electrochemistry
  • Electrodes
  • Glass
  • Oxidation-Reduction
  • Pharmaceutical Preparations / chemistry
  • Rotation

Substances

  • Pharmaceutical Preparations
  • Carbon
  • Albendazole