Abstract
[reaction: see text] A facile and highly selective indium-mediated allylation of hydrazones utilizing BINOL ligands is described. Chiral (R)-3,3'-bistrifluoromethylBINOL afforded homoallylic amines in up to 97% ee with stoichiometric ligand. Employing only 10 mol % ligand afforded selectivity of up to 92% ee.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Catalysis
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Hydrazones* / chemical synthesis
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Hydrazones* / chemistry
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Indium / chemistry*
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Ligands
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Molecular Structure
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Naphthols / chemistry*
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Stereoisomerism
Substances
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BINOL, naphthol
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Hydrazones
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Ligands
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Naphthols
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Indium