Abstract
Siglecs are sialic acid-binding Ig-like lectins expressed in a highly specific manner, and which are implicated in signaling and adhesive functions. The CD33-related siglecs represent a distinct subgroup that is undergoing rapid evolution within the innate immune system, with the potential to trigger apoptosis and provide inhibitory signals. CD22 is a well-characterised B cell restricted siglec that has been shown to mediate both sialic acid-dependent and -independent signaling functions in B cell regulation. As endocytic receptors, siglecs provide portals of entry for certain viral and bacterial pathogens, as well as therapeutic opportunities for targeting innate immune cells in disease.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Antigens, CD / genetics
-
Antigens, CD / immunology
-
Antigens, Differentiation, Myelomonocytic / genetics
-
Antigens, Differentiation, Myelomonocytic / immunology
-
Apoptosis / genetics
-
Apoptosis / immunology
-
Evolution, Molecular
-
Humans
-
Immunity, Innate / genetics
-
Immunity, Innate / immunology*
-
Lectins / genetics
-
Lectins / immunology*
-
Sialic Acid Binding Ig-like Lectin 2 / genetics
-
Sialic Acid Binding Ig-like Lectin 2 / immunology
-
Sialic Acid Binding Ig-like Lectin 3
-
Sialic Acid Binding Immunoglobulin-like Lectins
Substances
-
Antigens, CD
-
Antigens, Differentiation, Myelomonocytic
-
CD33 protein, human
-
Lectins
-
Sialic Acid Binding Ig-like Lectin 2
-
Sialic Acid Binding Ig-like Lectin 3
-
Sialic Acid Binding Immunoglobulin-like Lectins