A 59-year-old male presented with a painful nodule on the interscapular area of 20 year duration. The microscopic examination showed a myxomatous lobulated tumor composed of dendritic fusiform cells with some epithelioid and multinucleated cells typical of a nerve sheath myxoma. Immunohistochemical analysis demonstrated reactivity for S100 protein. Neither factor XIIIa nor epithelial membrane antigen (EMA) expression was found in the tumor cells. These findings suggest a schwannian origin for this tumor.