Light response differences in the superior colliculus of albino and pigmented rats

Neurosci Lett. 2005 Sep 9;385(2):143-7. doi: 10.1016/j.neulet.2005.05.034.

Abstract

Multi-unit visual responses to light intensities ranging from -6.46 to 0.81 logcd/m2 were recorded from the surface of the superior colliculus of dark-adapted normal pigmented and normal albino rats. Light sensitivity was significantly higher in albinos. The response onset latency was inversely proportional to the stimulus intensity. The progression of the stimulus intensity versus response onset latency curve showed a considerable difference between pigmented and albino rats. At low light levels, longer response onset latencies were recorded in pigmented rats than in albinos. This can be attributed to the transmission of rod-driven responses. The differences observed in the light response characteristics of albino rats may be indicative of their visual abnormalities.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Contrast Sensitivity / physiology*
  • Female
  • Male
  • Melanins / deficiency
  • Neurons / physiology
  • Photic Stimulation
  • Pigment Epithelium of Eye / physiopathology
  • Rats
  • Rats, Inbred ACI
  • Rats, Sprague-Dawley
  • Reaction Time / physiology
  • Retina / abnormalities
  • Retina / physiology*
  • Retina / physiopathology
  • Skin Pigmentation / physiology*
  • Species Specificity
  • Superior Colliculi / physiology*
  • Superior Colliculi / physiopathology
  • Visual Pathways / abnormalities
  • Visual Pathways / physiology*
  • Visual Pathways / physiopathology

Substances

  • Melanins