Abstract
Seven new 15-keto pregnane glycosides, namely Stemmosides E--K, were isolated from Solenostemma argel. Stemmosides E--J are characterized by the occurrence of an uncommon 14 beta proton configuration while stemmosides E and F possess in addition a rare enolic function in C-16. On the other hand, stemmosides G-J display an unusual C-17 alpha side chain. Their structures were established by ESI-MS and NMR experiments. Moreover, the effect of these compounds on the VEGF-induced in Kaposi's sarcoma cell proliferation was tested. Results indicated that all the compounds reduced the cell proliferation in a dose dependent manner.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Apocynaceae / chemistry*
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Cell Line, Tumor
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Cell Proliferation / drug effects*
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Glycosides / chemistry*
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Glycosides / isolation & purification
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Glycosides / pharmacology
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Plant Extracts / chemistry
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Pregnanes / chemistry*
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Pregnanes / isolation & purification
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Pregnanes / pharmacology
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Spectrometry, Mass, Electrospray Ionization
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Vascular Endothelial Growth Factor A / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Glycosides
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Plant Extracts
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Pregnanes
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Vascular Endothelial Growth Factor A
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stemmoside A