The paper describes the results of a clinical trial of itraconasole as suspension in the treatment of Candida-induced lower respiratory tract lesions in patients with pulmonary tuberculosis. The first course of the therapy stopped the growth of fungal culture in 34 (68%) patients; after its repeated course, there were 42 (84%) recovered patients out of 50. After the first course of orangul therapy, there was a decrease in the titer of fungal growth in 15 (30%) patients. The repeated course of the therapy resulted in fungal eradication in 8 of the 15 patients, a further decrease in the baseline titer of the fungi was observed in 4 patients. The treatment was ineffective only in 1 (2%) patient, which was associated with the progression of disseminated pulmonary tuberculosisand with the presence of the dose-dependent fungal strain C. glabrata.