Electrophysiological methods were used in experiments on 15 dogs for the study of topography of right atrial epicardial nerves, their connections with sinoatrial node, and possibilities of selective surgical denervation of sinoatrial node. Epicardial nerves were electro-coagulated or cryo-destructed in ventral, lateral and dorsal atrial zones near base of vena cava inferior. The following parameters were registered: heart rate, time of restoration of sinus node function, conduction through atrioventricular node, refractoriness of atria and atrioventricular node. Comparison of cardiac parameters before and after destruction of epicardial nerves showed that in lateral and ventral zones sympathetic nerves reach sinus node through lateral and ventral zones while parasympathetic -- along dorsal zone. Selective surgical destruction allows to modify sinus node function in a desired way.