DNA damaging activities of methanol extract of Ajuga postii and iridoid glucoside reptoside

Nat Prod Res. 2005 Jul;19(5):457-60. doi: 10.1080/14786410412331272095.

Abstract

An iridoid glucoside reptoside (1) has been isolated as a DNA damaging active agent by bioassay-guided fractionation of the methanol extract of Ajuga postii. Furthermore, from the acetone extract of A. postii two known triterpenic compounds ursolic acid, alpha-amyrin and two steroidal compounds (24S)-24-ethylcholesta-5,25-dien-3beta-ol and beta-sitosterol were isolated. Their structures were elucidated based on 1D and 2D NMR techniques and mass data.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Ajuga / chemistry*
  • DNA Damage*
  • Iridoids / chemistry*
  • Iridoids / toxicity
  • Oleanolic Acid / analogs & derivatives
  • Oleanolic Acid / chemistry
  • Plant Extracts / toxicity
  • Sitosterols / chemistry
  • Sterols / chemistry
  • Triterpenes / chemistry
  • Ursolic Acid

Substances

  • (24S)-24-ethylcholesta-5,25-dien-3beta-ol
  • Iridoids
  • Plant Extracts
  • Sitosterols
  • Sterols
  • Triterpenes
  • reptoside
  • gamma-sitosterol
  • Oleanolic Acid
  • beta-amyrin