Abstract
Bioactivity-guided fractionation of a MeOH-EtOAc extract from the young leaves of Nectandra lineata (Lauraceae), using a Trypanosoma cruzi bioassay resulted in the isolation of a novel norlignan 3'-methoxy-3,4-methylenedioxy-4',7-epoxy-9-nor-8,5'-neolignan-9'-acetoxy (1), together with the known compound, 3'-methoxy-3,4-methylenedioxy-4'-7-epoxy-9-nor-8,5'-neolignan-7,8'-diene (2). Compounds 1 and 2 were shown to inhibit the growth of T. cruzi epimastigotes in axenic culture.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemistry*
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Alkenes / isolation & purification
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Alkenes / pharmacology*
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Animals
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Lauraceae / chemistry*
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Lignans / chemistry*
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Lignans / isolation & purification
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Lignans / pharmacology*
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Plant Leaves / chemistry
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Trypanocidal Agents / chemistry*
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Trypanocidal Agents / isolation & purification
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Trypanocidal Agents / pharmacology*
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Trypanosoma cruzi / drug effects
Substances
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3'-methoxy-3,4-methylenedioxy-4',7-epoxy-9-nor-8,5'-neolignan-9'-acetoxy
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3'-methoxy-3,4-methylenedioxy-4'-7-epoxy-9-nor-8,5'-neolignan-7,8'-diene
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Alkenes
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Lignans
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Trypanocidal Agents