1H and 13C NMR spectral assignment of androstane derivatives

Ariadna Fuente; Mayra Reyes; Yoanna M Alvarez; José A Ruiz; Hermán Vélez; Omar Viñas-Bravo; Sara Montiel-Smith; Socorro Meza-Reyes; Jesús Sandoval-Ramírez

doi:10.1002/mrc.1605

1H and 13C NMR spectral assignment of androstane derivatives

Magn Reson Chem. 2005 Aug;43(8):676-8. doi: 10.1002/mrc.1605.

Authors

Ariadna Fuente¹, Mayra Reyes, Yoanna M Alvarez, José A Ruiz, Hermán Vélez, Omar Viñas-Bravo, Sara Montiel-Smith, Socorro Meza-Reyes, Jesús Sandoval-Ramírez

Affiliation

¹ Centro de Química Farmacéutica, Apartado Postal 16042, Ciudad de La Habana, Cuba.

PMID: 15937975
DOI: 10.1002/mrc.1605

Abstract

(1)H and (13)C NMR spectroscopic data for 5alpha-androstanes and halo-5alpha-androstanes with different substituents at positions C-3, C-9, C-11 and C-17 were examined and assigned by a combination of 1D and 2D NMR experiments. The substituent effects on the (13)C chemical shifts were compared with those of epi-androsterone, used as a reference compound. The coupling constants (n)J((19)F,(13)C) were measured for compounds 6, 8, 11 and 14.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Androstanes / chemistry*
Magnetic Resonance Spectroscopy / methods*
Magnetic Resonance Spectroscopy / standards*
Molecular Conformation
Reference Values

Substances

Androstanes