Cell biology: master regulators of sealing and healing

Curr Biol. 2005 Jun 7;15(11):R425-7. doi: 10.1016/j.cub.2005.05.034.

Abstract

The protective layer of the epidermis in Drosophila (cuticle) and mice (stratum corneum) are structurally unrelated. Yet new evidence suggests a conserved transcription factor, Grainyhead, controls both their development and the means by which both structures repair themselves.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • DNA-Binding Proteins / metabolism*
  • Dopa Decarboxylase / metabolism
  • Drosophila / genetics
  • Drosophila / physiology*
  • Drosophila Proteins
  • Epidermis / growth & development*
  • Gene Expression Regulation*
  • Mice / genetics
  • Mice / physiology*
  • Nuclear Proteins
  • Signal Transduction / physiology*
  • Transcription Factors / metabolism*
  • Tyrosine 3-Monooxygenase / metabolism
  • Wound Healing / genetics
  • Wound Healing / physiology*

Substances

  • DNA-Binding Proteins
  • Drosophila Proteins
  • ELF1 protein, human
  • Elf1 protein, mouse
  • Nuclear Proteins
  • Transcription Factors
  • grh protein, Drosophila
  • Tyrosine 3-Monooxygenase
  • Dopa Decarboxylase