Cell differentiation inducers derived from thalidomide

Tomomi Noguchi; Hiroyuki Miyachi; Ryohei Katayama; Mikihiko Naito; Yuichi Hashimoto

doi:10.1016/j.bmcl.2005.05.005

Cell differentiation inducers derived from thalidomide

Bioorg Med Chem Lett. 2005 Jul 1;15(13):3212-5. doi: 10.1016/j.bmcl.2005.05.005.

Authors

Tomomi Noguchi¹, Hiroyuki Miyachi, Ryohei Katayama, Mikihiko Naito, Yuichi Hashimoto

Affiliation

¹ Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

PMID: 15936192
DOI: 10.1016/j.bmcl.2005.05.005

Abstract

5-Hydroxy- and 4-amino-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (5HPP-33 and 4APP-33, respectively) have been shown to possess cell differentiation-inducing activity toward human leukemia cell line HL-60.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology
Cell Differentiation / drug effects*
Drug Screening Assays, Antitumor
Flow Cytometry
HL-60 Cells
Humans
Indoles
Isoindoles
Leukemia / drug therapy
Lipopolysaccharide Receptors / analysis
Structure-Activity Relationship
Thalidomide / analogs & derivatives*
Thalidomide / chemical synthesis

Substances

2-(2,6-diisopropylphenyl)-5-hydroxy-1H-isoindole-1,3-dione
Antineoplastic Agents
Indoles
Isoindoles
Lipopolysaccharide Receptors
Thalidomide