Abstract
In recent years important progress has been made studying the nucleocapsid (N) protein of hantaviruses. The N protein presents a good example of a multifunctional viral macromolecule. It is a major structural component of a virion that encapsidates viral RNA (vRNA). It also interacts with the virus polymerase (L protein) and one of the glycoproteins. On top of these "house keeping" duties, the N protein performs interactive "ambassadorial" functions interfering with important regulatory pathways in the infected cells.
MeSH terms
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Actin Cytoskeleton / metabolism
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Adaptor Proteins, Signal Transducing
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Animals
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Apoptosis
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Capsid Proteins / metabolism
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Capsid Proteins / physiology*
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Carrier Proteins / metabolism
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Co-Repressor Proteins
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Dimerization
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GTP-Binding Proteins / metabolism
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Glycoproteins / metabolism
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Hantavirus Infections / virology
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Humans
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Intracellular Signaling Peptides and Proteins / metabolism
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Models, Molecular
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Molecular Chaperones
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Myxovirus Resistance Proteins
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Nuclear Proteins / metabolism
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Orthohantavirus / chemistry
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Orthohantavirus / physiology
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Protein Binding
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RNA-Dependent RNA Polymerase / metabolism
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Viral Core Proteins / metabolism
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Viral Core Proteins / physiology*
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Viral Proteins / metabolism
Substances
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Adaptor Proteins, Signal Transducing
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Capsid Proteins
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Carrier Proteins
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Co-Repressor Proteins
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DAXX protein, human
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Glycoproteins
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Intracellular Signaling Peptides and Proteins
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Molecular Chaperones
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Myxovirus Resistance Proteins
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Nuclear Proteins
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Viral Core Proteins
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Viral Proteins
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nucleocapsid protein, Hantaan virus
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L protein, hantavirus
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RNA-Dependent RNA Polymerase
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GTP-Binding Proteins