Abstract
To evaluate the usefulness of detection of antibodies to hepatitis E virus (HEV) to screen for viraemic pigs, serum samples obtained from 1425 1-6-month-old pigs in Japan were tested for swine HEV RNA and IgG, IgM and IgA classes of anti-HEV antibody. Fifty-five (5 %) of the 1071 2-5-month-old pigs were positive for swine HEV RNA, but none of 218 1-month-old pigs or 136 6-month-old pigs had detectable HEV RNA. The prevalence of anti-HEV IgG among the viraemic pigs (67 %, 37/55) was similar to that among the non-viraemic pigs (55 %, 757/1370) and the prevalence of anti-HEV IgM among the viraemic pigs and non-viraemic pigs was 7 and 3 %, respectively. However, anti-HEV IgA was detected significantly more frequently among viraemic pigs than among non-viraemic pigs (55 vs 10 %, P<0.0001). These results suggest that anti-HEV IgA is more useful than anti-HEV IgM to screen for viraemic pigs.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Age Factors
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Animals
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Antibody Specificity
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Hepatitis Antibodies / blood*
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Hepatitis E / diagnosis
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Hepatitis E / epidemiology
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Hepatitis E / veterinary*
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Hepatitis E virus / genetics
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Hepatitis E virus / isolation & purification*
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Immunoglobulins / blood*
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Japan / epidemiology
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Molecular Sequence Data
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Phylogeny
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RNA, Viral / isolation & purification*
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Seroepidemiologic Studies
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Sus scrofa
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Swine Diseases / diagnosis
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Swine Diseases / epidemiology*
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Viremia / veterinary*
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Virology / methods*
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Zoonoses / epidemiology*
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Zoonoses / virology
Substances
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Hepatitis Antibodies
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Immunoglobulins
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RNA, Viral
Associated data
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GENBANK/AB194476
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GENBANK/AB194477
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GENBANK/AB194478
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