Live attenuated mutants of Mycobacterium tuberculosis as candidate vaccines against tuberculosis

Vasan K Sambandamurthy; William R Jacobs Jr

doi:10.1016/j.micinf.2005.04.001

Live attenuated mutants of Mycobacterium tuberculosis as candidate vaccines against tuberculosis

Microbes Infect. 2005 May;7(5-6):955-61. doi: 10.1016/j.micinf.2005.04.001.

Authors

Vasan K Sambandamurthy¹, William R Jacobs Jr

Affiliation

¹ Department of Microbiology and Immunology, Howard Hughes Medical Institute, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.

PMID: 15914065
DOI: 10.1016/j.micinf.2005.04.001

Abstract

The recent advances in genetic tools to manipulate Mycobacterium tuberculosis have led to the construction of defined mutants and to the study of their role in the virulence and pathogenesis of tuberculosis. The safety and vaccine potential of a few of these M. tuberculosis mutants as candidate vaccines against tuberculosis are discussed.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Mutation
Mycobacterium tuberculosis / genetics*
Mycobacterium tuberculosis / immunology
Tuberculosis / prevention & control
Tuberculosis Vaccines* / immunology
Tuberculosis Vaccines* / toxicity
Vaccines, Attenuated / immunology
Vaccines, Attenuated / toxicity

Substances

Tuberculosis Vaccines
Vaccines, Attenuated

Grants and funding

AI 26170/AI/NIAID NIH HHS/United States