Abstract
2-Phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives were synthesized and screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Interestingly, compounds 14, 15, and 17 showed similar inhibitory effects (89-92%, 66-69%, and 24-29% at 1000, 500, and 100 mol ratio to TPA, respectively) against EBV-EA with potencies comparable to those of glycyrrhetic acid, a known natural antitumor-promoter.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acridines / chemical synthesis*
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Acridines / chemistry
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Acridines / pharmacology*
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Anticarcinogenic Agents / chemical synthesis*
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Anticarcinogenic Agents / chemistry
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Anticarcinogenic Agents / pharmacology*
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Cell Line
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Humans
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Magnetic Resonance Spectroscopy
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Quinolones / chemical synthesis*
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Quinolones / chemistry
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Quinolones / pharmacology*
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Tetradecanoylphorbol Acetate / pharmacology
Substances
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9-oxo-9,10-dihydroacridine
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Acridines
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Anticarcinogenic Agents
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Quinolones
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2-phenyl-4-oxohydroquinoline
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Tetradecanoylphorbol Acetate