Synthesis and biological activity of new derivatives of 3-phenoxymethyl-4-R-D2-1,2,4-triazoline-5-thione

Acta Pol Pharm. 2004 Dec:61 Suppl:11-3.

Abstract

New derivatives of 1,2,4-triazoline-5-thione system were obtained. The effects of both these compounds AP-I (3-phenoxymethyl-4-phenyl-D2-1,2,4-triazoline-5-thione) and AP-II (3-phenoxymethyl-4-ethyl-D2-1,2,4-triazoline-5-thione) on the central nervous system (CNS) of mice were studied.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5-Hydroxytryptophan / pharmacology
  • Analgesics / chemical synthesis
  • Analgesics / pharmacology
  • Animals
  • Anti-Anxiety Agents / chemical synthesis
  • Anti-Anxiety Agents / pharmacology
  • Anticonvulsants / chemical synthesis
  • Anticonvulsants / pharmacology
  • Body Temperature / drug effects
  • Central Nervous System Agents / chemical synthesis*
  • Central Nervous System Agents / pharmacology*
  • Central Nervous System Agents / toxicity
  • Indicators and Reagents
  • Male
  • Mice
  • Pain Measurement
  • Psychomotor Performance / drug effects
  • Sleep / drug effects
  • Thiones / chemical synthesis*
  • Thiones / pharmacology*
  • Triazoles / chemical synthesis*
  • Triazoles / pharmacology*

Substances

  • 3-phenoxymethyl-4-R-D2-1,2,4-triazoline-5-thione
  • Analgesics
  • Anti-Anxiety Agents
  • Anticonvulsants
  • Central Nervous System Agents
  • Indicators and Reagents
  • Thiones
  • Triazoles
  • 5-Hydroxytryptophan