Basal forebrain cholinergic lesions in 7-day-old rats alter ultrasound vocalisations and homing behaviour

Behav Brain Res. 2005 Jun 3;161(1):169-72. doi: 10.1016/j.bbr.2005.01.011. Epub 2005 Feb 25.

Abstract

We analysed the effects of 192 IgG-saporin lesions on pnd 7 upon neonatal behavioural responses. Number of ultrasonic vocalisations (USVs) were recorded on pnds 9, 11 and 13. On pnd 13 rats underwent a homing test to measure olfactory orientation towards nest material. 192 IgG-saporin reduced the number of USVs at all ages considered while increasing number of entrancies into the nest area. These data suggest that early damage to the basal forebrain cholinergic nuclei induces significant changes in the rat behavioural repertoire as early as the second-postnatal week.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Animals
  • Animals, Newborn
  • Antibodies, Monoclonal / toxicity*
  • Behavior, Animal
  • Brain Diseases / chemically induced*
  • Brain Diseases / physiopathology
  • Cholinergic Agents / toxicity*
  • Homing Behavior / drug effects
  • Homing Behavior / physiology*
  • Immunotoxins / toxicity*
  • N-Glycosyl Hydrolases
  • Prosencephalon / growth & development
  • Prosencephalon / injuries
  • Prosencephalon / physiopathology*
  • Rats
  • Ribosome Inactivating Proteins, Type 1
  • Saporins
  • Time Factors
  • Ultrasonics
  • Vocalization, Animal / drug effects
  • Vocalization, Animal / physiology*

Substances

  • 192 IgG-saporin
  • Antibodies, Monoclonal
  • Cholinergic Agents
  • Immunotoxins
  • Ribosome Inactivating Proteins, Type 1
  • N-Glycosyl Hydrolases
  • Saporins