Identification of the MHC class I B locus in cynomolgus monkeys

Akihiko Uda; Kiyoshi Tanabayashi; Osamu Fujita; Akitoyo Hotta; Keiji Terao; Akio Yamada

doi:10.1007/s00251-005-0782-6

Identification of the MHC class I B locus in cynomolgus monkeys

Immunogenetics. 2005 May;57(3-4):189-97. doi: 10.1007/s00251-005-0782-6. Epub 2005 Mar 3.

Authors

Akihiko Uda¹, Kiyoshi Tanabayashi, Osamu Fujita, Akitoyo Hotta, Keiji Terao, Akio Yamada

Affiliation

¹ Department of Veterinary Science, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.

PMID: 15900490
DOI: 10.1007/s00251-005-0782-6

Abstract

By determining the nucleotide sequences of more than 700 cDNA clones isolated from 16 cynomolgus monkeys, we identified 26 Mafa-B alleles. In addition, nine sequences with similarity to Mamu-I alleles were identified. Since multiple Mafa-B alleles were found in each individual, it was strongly suggested that the cynomolgus MHC class I B locus might be duplicated and that the Mafa-I locus was derived from the B locus by gene duplication, as in the case of the Mamu-I locus of rhesus monkeys.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Amino Acid Sequence
Animals
Base Sequence
DNA, Complementary / genetics
Female
Gene Duplication
Genes, MHC Class I*
Haplotypes
Macaca fascicularis / genetics*
Macaca fascicularis / immunology*
Macaca mulatta / genetics
Macaca mulatta / immunology
Male
Molecular Sequence Data
Pedigree
Phylogeny
Sequence Homology, Amino Acid
Species Specificity

Substances

DNA, Complementary

Associated data

GENBANK/AB154760
GENBANK/AB154761
GENBANK/AB154762
GENBANK/AB154763
GENBANK/AB154764
GENBANK/AB154765
GENBANK/AB154766
GENBANK/AB154767
GENBANK/AB154768
GENBANK/AB154769
GENBANK/AB154770
GENBANK/AB154771
GENBANK/AB154772
GENBANK/AB154773