Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues

Chem Commun (Camb). 2005 May 28:(20):2555-7. doi: 10.1039/b502325d. Epub 2005 Apr 14.

Abstract

Substituted 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Pairing
  • Cytosine / analysis*
  • Cytosine / chemistry
  • DNA / chemistry*
  • Guanine / analysis*
  • Guanine / chemistry
  • Hydrogen Bonding
  • Nucleic Acid Conformation
  • Nucleosides / chemical synthesis
  • Nucleosides / chemistry*
  • Oligonucleotides / chemistry
  • Pyrimidinones / chemical synthesis
  • Pyrimidinones / chemistry*
  • Thymine / analysis
  • Thymine / chemistry

Substances

  • Nucleosides
  • Oligonucleotides
  • Pyrimidinones
  • triplex DNA
  • Guanine
  • Cytosine
  • DNA
  • Thymine