Schwannoma with neuroblastoma-like rosettes: an unusual morphologic variant

Am J Dermatopathol. 2005 Jun;27(3):243-6. doi: 10.1097/01.dad.0000143706.69170.62.

Abstract

In the past ten years, seven cases of schwannomas with giant fibrillar rosettes or perivascular rosettes have been reported. As these unusual variants of schwannomas had areas with hyperchromatic, small round cells recapitulating the appearance of a neuroblastoma, they received the descriptive name of neuroblastoma-like schwannomas. We herein report two additional cases of this unique variant of schwannoma and provide differential diagnostic considerations.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunohistochemistry
  • Neurilemmoma / metabolism
  • Neurilemmoma / pathology*
  • Neuroblastoma / pathology
  • S100 Proteins / metabolism
  • Soft Tissue Neoplasms / metabolism
  • Soft Tissue Neoplasms / pathology*

Substances

  • S100 Proteins