Abstract
During the epidemic of severe acute respiratory syndrome in 2003, a 27-year- old Japanese woman presented a high fever and acute respiratory distress with pulmonary infiltrates after traveling to a high-risk area. An alternative diagnosis was made as Epstein-Barr virus-associated hemophagocytic syndrome, based on the proliferation of macrophages with hemophagocytosis in the bone marrow and Epstein-Barr viral marker profiles. Virus-associated hemophagocytic syndrome in an international traveler should be included in the differential diagnosis of severe acute respiratory syndrome.
MeSH terms
-
Adult
-
Antibodies, Viral / immunology
-
Biopsy, Needle
-
Bone Marrow / pathology
-
DNA, Viral / genetics
-
Diagnosis, Differential
-
Epstein-Barr Virus Infections / diagnosis*
-
Epstein-Barr Virus Infections / virology
-
Female
-
Follow-Up Studies
-
Genome, Viral
-
Glucocorticoids / therapeutic use
-
Herpesvirus 4, Human* / drug effects
-
Herpesvirus 4, Human* / genetics
-
Herpesvirus 4, Human* / immunology
-
Histiocytosis, Non-Langerhans-Cell / diagnosis*
-
Histiocytosis, Non-Langerhans-Cell / drug therapy
-
Histiocytosis, Non-Langerhans-Cell / virology
-
Humans
-
Methylprednisolone / therapeutic use
-
Polymerase Chain Reaction
-
Radiography, Thoracic
-
Severe Acute Respiratory Syndrome / diagnosis*
-
Thailand
-
Tomography, X-Ray Computed
-
Travel*
Substances
-
Antibodies, Viral
-
DNA, Viral
-
Glucocorticoids
-
Methylprednisolone