The yeast Mediator complex and its regulation

Trends Biochem Sci. 2005 May;30(5):240-4. doi: 10.1016/j.tibs.2005.03.008.

Abstract

The Mediator complex acts as a bridge, conveying regulatory information from enhancers and other control elements to the basal RNA polymerase II transcription machinery. Mediator is required for the regulated transcription of nearly all RNA polymerase II-dependent genes in Saccharomyces cerevisiae, and post-translational modifications of specific Mediator subunits can affect global patterns of gene transcription.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Fungal*
  • Mediator Complex
  • Multiprotein Complexes
  • Protein Processing, Post-Translational*
  • Protein Subunits / genetics
  • Protein Subunits / metabolism
  • RNA Polymerase II / metabolism
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Trans-Activators / genetics
  • Trans-Activators / metabolism
  • Transcription, Genetic

Substances

  • GAL11 protein, S cerevisiae
  • Mediator Complex
  • Multiprotein Complexes
  • Protein Subunits
  • Saccharomyces cerevisiae Proteins
  • Trans-Activators
  • RNA Polymerase II