Deficits in sensorimotor control are experienced immediately after nerve injury due to changes in the periphery and central nervous system. Muscle denervation and sensory loss often disrupt prehensile coordination requiring the use of alternative strategies. To effectively foster coordination postinjury clinicians should address not only impairments and function but motor control issues through the prescription of specific sensory and motor experiences. Engagement in carefully planned, therapeutic activity can take advantage of the nervous systems' ability to regenerate and reorganize following nerve lesions. This article reviews motor control issues and neural reorganization concepts that may influence the recovery of skilled prehension following upper limb nerve injury. It also provides clinical guidelines for examining and enhancing coordination.