Abstract
A major benzoquinone pigment, embelin (1), was isolated from the underground parts of Lysimachia punctata. Compound 1 showed a significant cytotoxic activity in vitro against B16 and XC cell lines with ED50 values of 13 microg/ml and 8 microg/ml, respectively.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Benzoquinones / isolation & purification
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Benzoquinones / pharmacology*
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Cell Line, Tumor
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Cells, Cultured
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Dose-Response Relationship, Drug
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Humans
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Molecular Structure
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Primulaceae / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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Benzoquinones
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embelin